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MBE Advance Access originally published online on October 20, 2006
Molecular Biology and Evolution 2007 24(1):306-314; doi:10.1093/molbev/msl157
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© The Author 2006. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

Research Articles

Pervasive Adaptive Evolution among Interactors of the Drosophila Hybrid Inviability Gene, Nup96

Daven C. Presgraves*,{dagger} and Wolfgang Stephan*

* Section of Evolutionary Biology, Biocenter, University of Munich, Planegg-Martinsried, Germany
{dagger} Department of Biology, University of Rochester

E-mail: dvnp{at}mail.rochester.edu.

Accepted for publication October 17, 2006.

Nup96 is involved in a lethal hybrid incompatibility between 2 fruit fly species, Drosophila melanogaster and Drosophila simulans. Recurrent adaptive evolution drove the rapid functional divergence of Nup96 in both the D. melanogaster and the D. simulans lineages. Functional divergence of Nup96 between these 2 species is unexpected as Nup96 encodes part of the Nup107 subcomplex, an architectural component of nuclear pore complexes, the macromolecular channels in nuclear envelopes that mediate nucleocytoplasmic traffic in all eukaryotes. Here we study the evolutionary histories of 5 of Nup96's protein interactors—3 stable Nup107 subcomplex proteins (Nup75, Nup107, and Nup133) and 2 mobile nucleoporins (Nup98 and Nup153)—and show that all 5 have experienced recurrent adaptive evolution. These results are consistent with selection-driven coevolution among molecular interactors within species causing the incidental evolution of incompatible interactions seen in hybrids between species. We suggest that genetic conflict–driven processes may have contributed to the rapid molecular evolution of Nup107 subcomplex genes.

Key Words: Drosophila • hybrid inviability • hybrid incompatibility • speciation

Jianzhi Zhang, Associate Editor


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