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MBE Advance Access originally published online on February 28, 2006
Molecular Biology and Evolution 2006 23(5):1016-1018; doi:10.1093/molbev/msj116
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© The Author 2006. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

Letter

Microsatellite Variation, Repeat Array Length, and Population History of Plasmodium vivax

M. Imwong*, D. Sudimack{dagger}, S. Pukrittayakamee*, L. Osorio{ddagger}, J. M. Carlton§, N. P. J. Day*,||, N. J. White*,|| and T. J. C. Anderson{dagger}

* Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; {dagger} Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas; {ddagger} Malaria Research Group, International Centre for Medical Research and Training, Cali, Colombia; § The Institute for Genomic Research, Rockville, Maryland; and || Centre for Tropical Medicine and Vaccinology, Churchill Hospital, Oxford, United Kingdom

E-mail: tanderso@darwin.sfbr.org.

Key Words: microsatellite • array length • heterozygosity • selection • bottleneck

The first 10% of the full text of this article appears below.

A recent paper (Leclerc et al. 2004Go) described limited variation in dinucleotide microsatellites from Plasmodium vivax, suggesting very recent bottlenecks or genome-wide selective events. We describe patterns of variation in 11 dinucleotide microsatellites in P. vivax populations from Colombia, India, and Thailand. We find abundant variation with heterozygosity of 0.64, 0.76, and 0.77, respectively, in the three countries. The discrepancy between these two studies results is simply explained by the differences in the size of repeat arrays. The microsatellites studied by Leclerc et al. (2004)Go have very few repeats (median 5.5, range 4–13) and so would not be expected to be variable. Plasmodium vivax microsatellites show comparable levels of variation to those in Plasmodium falciparum when repeat array length is taken into account and provide no support for recent bottlenecks or widespread selective purging . . . [Full Text of this Article]


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