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MBE Advance Access originally published online on January 11, 2006
Molecular Biology and Evolution 2006 23(4):784-789; doi:10.1093/molbev/msj090
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© The Author 2006. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

Research Article

The Evolutionary Rate of a Protein Is Influenced by Features of the Interacting Partners

Takashi Makino and Takashi Gojobori

Center for Information Biology and DNA Data Bank of Japan, National Institute of Genetics, Yata, Mishima, Japan

E-mail: tgojobor{at}genes.nig.ac.jp.

Rates of protein evolution are thought to be influenced by features of protein-protein interaction (PPI). However, the most important features of interaction for determining the evolutionary rate are poorly understood. Here, we consider four categories for PPIs in Saccharomyces cerevisiae. Properties we consider are the extent to which proteins interact with proteins of the same function or different function (DF) and the extent to which these interactions involve connections in the dense part or sparse part (SP) of a PPI network. Our findings are that proteins with DF-SP interactions evolve at the slowest rate of all the proteins examined.

Key Words: protein-protein interaction • functional module • Saccharomyces cerevisiae • evolution


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