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MBE Advance Access originally published online on December 20, 2005
Molecular Biology and Evolution 2006 23(3):479-481; doi:10.1093/molbev/msj076
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© The Author 2005. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

Letter

The Contribution of LTR Retrotransposon Sequences to Gene Evolution in Mus musculus

Jeremy D. DeBarry, Eric W. Ganko1, Eugene M. McCarthy and John F. McDonald2

Department of Genetics, University of Georgia

E-mail: john.mcdonald{at}biology.gatech.edu.

Approximately 1.5% of mouse genes (Mus musculus) contain long terminal repeat retrotransposon sequences (LRS). Consistent with earlier findings in Caenorhabditis elegans, Drosophila melanogaster, and Homo sapiens, LRS are more likely to be associated with newly evolved genes. Evidence is presented that LRS are often recruited as novel exons or as spliced additions to existing exons. These novel gene configurations may be expressed initially as alternative transcripts providing an opportunity for the evolution of new gene function.

Key Words: LTR retrotransposon • gene evolution • Mus musculus • mouse


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