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MBE Advance Access originally published online on September 6, 2006
Molecular Biology and Evolution 2006 23(12):2268-2270; doi:10.1093/molbev/msl105
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© The Author 2006. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

Letters

Difference between Evolutionarily Effective and Germ line Mutation Rate Due to Stochastically Varying Haplogroup Size

Lev A. Zhivotovsky*, Peter A. Underhill{dagger} and Marcus W. Feldman{ddagger}

* N.I.Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, Russia
{dagger} Department of Genetics, Stanford University Medical School
{ddagger} Department of Biological Sciences, Stanford University

E-mail: levazh{at}gmail.com.

Within a Y-chromosome haplogroup defined by unique event mutations, variation in microsatellites can accumulate due to their rapid mutation. Estimates based on pedigrees for the Y-chromosome microsatellite mutation rate are 3 or more times greater than the same estimates from evolutionary considerations. We show by simulation that the haplogroups that survive the stochastic processes of drift and extinction accumulate microsatellite variation at a lower rate than predicted from corresponding pedigree estimates; in particular, under constant total population size, the accumulated variance is on average 3–4 times smaller.

Key Words: microsatellite • Y chromosome • mutation rate • haplogroup


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