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MBE Advance Access originally published online on September 21, 2005
Molecular Biology and Evolution 2006 23(1):7-9; doi:10.1093/molbev/msj021
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© The Author 2005. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

Letter

Choosing Appropriate Substitution Models for the Phylogenetic Analysis of Protein-Coding Sequences

Beth Shapiro1, Andrew Rambaut1 and Alexei J. Drummond1,2

Department of Zoology, University of Oxford, Oxford, United Kingdom

E-mail: andrew.rambaut{at}zoo.ox.ac.uk.

Although phylogenetic inference of protein-coding sequences continues to dominate the literature, few analyses incorporate evolutionary models that consider the genetic code. This problem is exacerbated by the exclusion of codon-based models from commonly employed model selection techniques, presumably due to the computational cost associated with codon models. We investigated an efficient alternative to standard nucleotide substitution models, in which codon position (CP) is incorporated into the model. We determined the most appropriate model for alignments of 177 RNA virus genes and 106 yeast genes, using 11 substitution models including one codon model and four CP models. The majority of analyzed gene alignments are best described by CP substitution models, rather than by standard nucleotide models, and without the computational cost of full codon models. These results have significant implications for phylogenetic inference of coding sequences as they make it clear that substitution models incorporating CPs not only are a computationally realistic alternative to standard models but may also frequently be statistically superior.

Key Words: phylogenetic inference • protein-coding sequences • substitution models


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