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MBE Advance Access originally published online on December 1, 2004
Molecular Biology and Evolution 2005 22(3):741-746; doi:10.1093/molbev/msi064
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Molecular Biology and Evolution vol. 22 no. 3 © Society for Molecular Biology and Evolution 2004; all rights reserved.

Research Article

Recurrent Recruitment of the THAP DNA-Binding Domain and Molecular Domestication of the P-Transposable Element

H. Quesneville, D. Nouaud and D. Anxolabehere

Laboratoire Dynamique du Génome et Evolution, Institut Jacques Monod, Universités Paris 6 et 7, Paris, France

E-mail: hq{at}ccr.jussieu.fr.

The recently described THAP domain motif characterizes a DNA-binding domain (DBD) that is widely conserved in human and in animals. It presents a similarity with the DBD of the P element transposase of D. melanogaster. We show here that the P Drosophila neogenes derived from P-transposable elements conserve the THAP domain. Moreover, secondary rearrangements by exon shuffling indicate the recurrent recruitment of this domain by the host genome. As P sequences and THAP genes are found together in many animal genomes, we discuss the possibility that the THAP proteins have acquired their domain as a result of recurrent molecular domestication of P-transposable elements.

Key Words: transposable elements • molecular evolution • bioinformatic analyses


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