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MBE Advance Access originally published online on October 13, 2004
Molecular Biology and Evolution 2005 22(2):265-272; doi:10.1093/molbev/msi014
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Molecular Biology and Evolution vol. 22 no. 2 © Society for Molecular Biology and Evolution 2005; all rights reserved.

Research Article

Non-African Origin of a Local Beneficial Mutation in D. melanogaster

F. Catania and C. Schlötterer

Institut für Tierzucht und Genetik, Wien, Austria

E-mail: christian.schloetterer{at}vu-wien.ac.at.

It is well understood that the out-of-Africa habitat expansion of D. melanogaster was associated with the fixation of many beneficial mutations. Nevertheless, it is not clear yet whether these beneficial mutations segregated already in Africa or originated outside of Africa. In this article, we describe an ongoing selective sweep specific to one European population. One microsatellite allele has increased in a population from The Netherlands to a frequency of 18%, whereas it is virtually absent in 12 other European populations. The selective sweep resulted in a genomic region of more than 600 kb that is identical by descent. This is probably the first evidence of a beneficial mutation that has arisen outside of Africa and has resulted in a selective sweep localized in a population from The Netherlands.

Key Words: local adaptation • allele frequency • microsatellite • partial selective sweep


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