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MBE Advance Access originally published online on May 26, 2004
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Mol. Biol. Evol. 21(9):1613-1619. 2004
DOI: 10.1093/molbev/msh174
© 2004 by the Society for Molecular Biology and Evolution. ISSN: 0737-4038

Genomic Analysis of Drosophila melanogaster Telomeres: Full-length Copies of HeT-A and TART Elements at Telomeres

José P. Abad1,*, Beatriz de Pablos1,2,*, Kazutoyo Osoegawa3, Pieter J. de Jong3, Antonia Martín-Gallardo2 and Alfredo Villasante1

1 Centro de Biología Molecular Severo Ochoa (CBMSO), CSIC-UAM. Madrid, Spain
2 Servicio Interdepartamental de Investigación (SIdI), UAM, Madrid, Spain
3 Children's Hospital Oakland Research Institute (CHORI), Oakland, Calif.

E-mail: avillasante{at}cbm.uam.es.

Abstract

The repetitive nature of heterochromatin hampers its analysis in general genome-sequencing projects. Specific studies are needed to extend the sequence into telomeric and centromeric heterochromatin. Drosophila telomeres lack the telomerase-generated repeats that are characteristic of other eukaryotic chromosomes. Instead, they consist of tandem arrays of HeT-A and TART elements. Herein, we present the genomic organization of the telomeres in the isogenic strain (y; cn bw sp) that was used for the Drosophila melanogaster sequencing project. The data indicate that the canonical features of telomere organization are widely conserved in evolution. In addition, we have identified full-length elements, likely competent elements, for HeT-A and TART.

Key Words: telomeres • telomeric retrotransposons • Drosophila


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