Skip Navigation


MBE Advance Access originally published online on March 10, 2004
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
21/6/1081    most recent
msh110v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (83)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Richly, E.
Right arrow Articles by Leister, D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Richly, E.
Right arrow Articles by Leister, D.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Mol. Biol. Evol. 21(6):1081-1084. 2004
DOI: 10.1093/molbev/msh110
© 2004 by the Society for Molecular Biology and Evolution. ISSN: 0737-4038

NUMTs in Sequenced Eukaryotic Genomes

Erik Richly and Dario Leister

Max-Planck-Institut für Züchtungsforschung, Köln, Germany

E-mail: leister{at}mpiz-koeln.mpg.de.

Mitochondrial DNA sequences are frequently transferred to the nucleus giving rise to the so-called nuclear mitochondrial DNA (NUMT). Analysis of 13 eukaryotic species with sequenced mitochondrial and nuclear genomes reveals a large interspecific variation of NUMT number and size. Copy number ranges from none or few copies in Anopheles, Caenorhabditis, Plasmodium, Drosophila, and Fugu to more than 500 in human, rice, and Arabidopsis. The average size is between 62 (baker's yeast) and 647 bps (Neurospora), respectively. A correlation between the abundance of NUMTs and the size of the nuclear or the mitochondrial genomes, or of the nuclear gene density, is not evident. Other factors, such as the number and/or stability of mitochondria in the germline, or species-specific mechanisms controlling accumulation/loss of nuclear DNA, might be responsible for the interspecific diversity in NUMT accumulation.

Key Words: duplication • gene transfer • genome evolution • mitochondria • NUMT • pseudogene


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Nucleic Acids ResHome page
T. T. Torres, M. Dolezal, C. Schlotterer, and B. Ottenwalder
Expression profiling of Drosophila mitochondrial genes via deep mRNA sequencing
Nucleic Acids Res., October 20, 2009; (2009) gkp856v1.
[Abstract] [Full Text] [PDF]

Home page
 Eukaryot CellHome page
A. C. Frank and K. H. Wolfe
Evolutionary Capture of Viral and Plasmid DNA by Yeast Nuclear Chromosomes
Eukaryot. Cell, October 1, 2009; 8(10): 1521 - 1531.
[Abstract] [Full Text] [PDF]

Home page
 Mol Biol EvolHome page
E. Hazkani-Covo
Mitochondrial Insertions into Primate Nuclear Genomes Suggest the Use of numts as a Tool for Phylogeny
Mol. Biol. Evol., October 1, 2009; 26(10): 2175 - 2179.
[Abstract] [Full Text] [PDF]

Home page
 Genome ResHome page
D. R. Smith, A. R. Quinlan, H. E. Peckham, K. Makowsky, W. Tao, B. Woolf, L. Shen, W. F. Donahue, N. Tusneem, M. P. Stromberg, et al.
Rapid whole-genome mutational profiling using next-generation sequencing technologies
Genome Res., October 1, 2008; 18(10): 1638 - 1642.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
H. Song, J. E. Buhay, M. F. Whiting, and K. A. Crandall
Many species in one: DNA barcoding overestimates the number of species when nuclear mitochondrial pseudogenes are coamplified
PNAS, September 9, 2008; 105(36): 13486 - 13491.
[Abstract] [Full Text] [PDF]

Home page
 Phil Trans R Soc BHome page
J. L Boore and S. I Fuerstenberg
Beyond linear sequence comparisons: the use of genome-level characters for phylogenetic reconstruction
Phil Trans R Soc B, April 27, 2008; 363(1496): 1445 - 1451.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
A. N. Lough, L. M. Roark, A. Kato, T. S. Ream, J. C. Lamb, J. A. Birchler, and K. J. Newton
Mitochondrial DNA Transfer to the Nucleus Generates Extensive Insertion Site Variation in Maize
Genetics, January 1, 2008; 178(1): 47 - 55.
[Abstract] [Full Text] [PDF]

Home page
 Genome ResHome page
J. U. Pontius, J. C. Mullikin, D. R. Smith, Agencourt Sequencing Team, K. Lindblad-Toh, S. Gnerre, M. Clamp, J. Chang, R. Stephens, B. Neelam, et al.
Initial sequence and comparative analysis of the cat genome
Genome Res., November 1, 2007; 17(11): 1675 - 1689.
[Abstract] [Full Text] [PDF]

Home page
 Mol Biol EvolHome page
D. Wang, Y.-W. Wu, A. C.-C. Shih, C.-S. Wu, Y.-N. Wang, and S.-M. Chaw
Transfer of Chloroplast Genomic DNA to Mitochondrial Genome Occurred At Least 300 MYA
Mol. Biol. Evol., September 1, 2007; 24(9): 2040 - 2048.
[Abstract] [Full Text] [PDF]

Home page
 J HeredHome page
A. Antunes, J. Pontius, M. J. Ramos, S. J. O'Brien, and W. E. Johnson
Mitochondrial Introgressions into the Nuclear Genome of the Domestic Cat
J. Hered., July 28, 2007; (2007) esm062v1.
[Abstract] [Full Text] [PDF]

Home page
 Mol Biol EvolHome page
S. K. Behura
Analysis of Nuclear Copies of Mitochondrial Sequences in Honeybee (Apis mellifera) Genome
Mol. Biol. Evol., July 1, 2007; 24(7): 1492 - 1505.
[Abstract] [Full Text] [PDF]

Home page
 Mol Biol EvolHome page
P. Pamilo, L. Viljakainen, and A. Vihavainen
Exceptionally High Density of NUMTs in the Honeybee Genome
Mol. Biol. Evol., June 1, 2007; 24(6): 1340 - 1346.
[Abstract] [Full Text] [PDF]

Home page
 J HeredHome page
F. Rodriguez, J. Albornoz, and A. Dominguez
Cytochrome b Pseudogene Originated from a Highly Divergent Mitochondrial Lineage in Genus Rupicapra
J. Hered., May 1, 2007; 98(3): 243 - 249.
[Abstract] [Full Text] [PDF]

Home page
 Mol Biol EvolHome page
E. Hazkani-Covo and D. Graur
A Comparative Analysis of numt Evolution in Human and Chimpanzee
Mol. Biol. Evol., January 1, 2007; 24(1): 13 - 18.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
N. E. Schlick, M. I. Jensen-Seaman, K. Orlebeke, A. E. Kwitek, H. J. Jacob, and J. Lazar
Sequence analysis of the complete mitochondrial DNA in 10 commonly used inbred rat strains
Am J Physiol Cell Physiol, December 1, 2006; 291(6): C1183 - C1192.
[Abstract] [Full Text] [PDF]

Home page
 Genome ResHome page
N. Kaplan and M. Linial
ProtoBee: Hierarchical classification and annotation of the honey bee proteome
Genome Res., November 1, 2006; 16(11): 1431 - 1438.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
M. E. Welch, M. Z. Darnell, and D. E. McCauley
Variable Populations Within Variable Populations: Quantifying Mitochondrial Heteroplasmy in Natural Populations of the Gynodioecious Plant Silene vulgaris
Genetics, October 1, 2006; 174(2): 829 - 837.
[Abstract] [Full Text] [PDF]

Home page
 Genome ResHome page
C. Simons, M. Pheasant, I. V. Makunin, and J. S. Mattick
Transposon-free regions in mammalian genomes
Genome Res., February 1, 2006; 16(2): 164 - 172.
[Abstract] [Full Text] [PDF]

Home page
 Phil Trans R Soc BHome page
R. D Ward, T. S Zemlak, B. H Innes, P. R Last, and P. D.N Hebert
DNA barcoding Australia's fish species
Phil Trans R Soc B, October 29, 2005; 360(1462): 1847 - 1857.
[Abstract] [Full Text] [PDF]

Home page
 Phil Trans R Soc BHome page
J. G Lorenz, W. E Jackson, J. C Beck, and R. Hanner
The problems and promise of DNA barcodes for species diagnosis of primate biomaterials
Phil Trans R Soc B, October 29, 2005; 360(1462): 1869 - 1877.
[Abstract] [Full Text] [PDF]

Home page
 Plant Physiol.Home page
C. Y. Huang, N. Grunheit, N. Ahmadinejad, J. N. Timmis, and W. Martin
Mutational Decay and Age of Chloroplast and Mitochondrial Genomes Transferred Recently to Angiosperm Nuclear Chromosomes
Plant Physiology, July 1, 2005; 138(3): 1723 - 1733.
[Abstract] [Full Text] [PDF]

Home page
 Genome ResHome page
C. Noutsos, E. Richly, and D. Leister
Generation and evolutionary fate of insertions of organelle DNA in the nuclear genomes of flowering plants
Genome Res., May 1, 2005; 15(5): 616 - 628.
[Abstract] [Full Text] [PDF]

Home page
 Mol Biol EvolHome page
J. Pons and A. P. Vogler
Complex Pattern of Coalescence and Fast Evolution of a Mitochondrial rRNA Pseudogene in a Recent Radiation of Tiger Beetles
Mol. Biol. Evol., April 1, 2005; 22(4): 991 - 1000.
[Abstract] [Full Text] [PDF]

Home page
 Plant Physiol.Home page
S. W. Clifton, P. Minx, C. M.-R. Fauron, M. Gibson, J. O. Allen, H. Sun, M. Thompson, W. B. Barbazuk, S. Kanuganti, C. Tayloe, et al.
Sequence and Comparative Analysis of the Maize NB Mitochondrial Genome
Plant Physiology, November 1, 2004; 136(3): 3486 - 3503.
[Abstract] [Full Text] [PDF]

Home page
 Mol Biol EvolHome page
E. Richly and D. Leister
NUPTs in Sequenced Eukaryotes and Their Genomic Organization in Relation to NUMTs
Mol. Biol. Evol., October 1, 2004; 21(10): 1972 - 1980.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.