MBE Advance Access originally published online on December 5, 2003
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mol. Biol. Evol. 21(2):286-294. 2004
DOI: 10.1093/molbev/msh020
© 2004 by the Society for Molecular Biology and Evolution. ISSN: 0737-4038
Effect of Strong Directional Selection on Weakly Selected Mutations at Linked Sites: Implication for Synonymous Codon Usage
Department of Biological Statistics and Computational Biology, Cornell University
E-mail: ykim{at}mail.rochester.edu.
The fixation of weakly selected mutations can be greatly influenced by strong directional selection at linked loci. Here, I investigate a two-locus model in which weakly selected, reversible mutations occur at one locus and recurrent strong directional selection occurs at the other locus. This model is analogous to selection on codon usage at synonymous sites linked to nonsynonymous sites under strong directional selection. Two approximations obtained here describe the expected frequency of the weakly selected preferred alleles at equilibrium. These approximations, as well as simulation results, show that the level of codon bias declines with an increasing rate of substitution at the strongly selected locus, as expected from the well-understood theory that selection at one locus reduces the efficacy of selection at linked loci. These solutions are used to examine whether the negative correlation between codon bias and nonsynonymous substitution rates recently observed in Drosophila can be explained by this hitchhiking effect. It is shown that this observation can be reasonably well accounted for if a large fraction of the nonsynonymous substitutions on genes in the data set are driven by strong directional selection.
Key Words: codon bias • linkage • interference • hitchhiking • Drosophila
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  F. C. Almeida and R. DeSalle Evidence of Adaptive Evolution of Accessory Gland Proteins in Closely Related Species of the Drosophila repleta Group Mol. Biol. Evol., September 1, 2008; 25(9): 2043 - 2053. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Ke, X. H.-F. Zhang, and L. A. Chasin Positive selection acting on splicing motifs reflects compensatory evolution Genome Res., April 1, 2008; 18(4): 533 - 543. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Andolfatto Hitchhiking effects of recurrent beneficial amino acid substitutions in the Drosophila melanogaster genome Genome Res., December 1, 2007; 17(12): 1755 - 1762. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Maside and B. Charlesworth Patterns of Molecular Variation and Evolution in Drosophila americana and Its Relatives Genetics, August 1, 2007; 176(4): 2293 - 2305. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Loewe and B. Charlesworth Background Selection in Single Genes May Explain Patterns of Codon Bias Genetics, March 1, 2007; 175(3): 1381 - 1393. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Loewe, B. Charlesworth, C. Bartolome, and V. Noel Estimating Selection on Nonsynonymous Mutations Genetics, February 1, 2006; 172(2): 1079 - 1092. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. D. Singh, J. C. Davis, and D. A. Petrov X-Linked Genes Evolve Higher Codon Bias in Drosophila and Caenorhabditis Genetics, September 1, 2005; 171(1): 145 - 155. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. M. Hambuch and J. Parsch Patterns of Synonymous Codon Usage in Drosophila melanogaster Genes With Sex-Biased Expression Genetics, August 1, 2005; 170(4): 1691 - 1700. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Lynch and J. S. Conery Response to Comment on "The Origins of Genome Complexity" Science, November 5, 2004; 306(5698): 978b - 978b. [Full Text] [PDF]
|
|
|
|
|
|
Z. Zhang, T. M. Hambuch, and J. Parsch Molecular Evolution of Sex-Biased Genes in Drosophila Mol. Biol. Evol., November 1, 2004; 21(11): 2130 - 2139. [Abstract] [Full Text] [PDF]
|
|