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MBE Advance Access originally published online on May 30, 2003
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Mol. Biol. Evol. 20(8):1252-1259. 2003
DOI: 10.1093/molbev/msg149
© 2003 by the Society for Molecular Biology and Evolution. ISSN: 0737-4038

A Codon-Based Model of Host-Specific Selection in Parasites, with an Application to the Influenza A Virus

Roald Forsberg1, and Freddy Bugge Christiansen

Bioinformatics Research Center (BiRC), Department of Genetics and Ecology, The Institute of Biological Sciences, University of rhus, rhus, Denmark

E-mail: forsberg{at}stats.ox.ac.uk.

Parasites sometimes expand their host range by acquiring a new host species. After a host change event, the selective regime acting on a given parasite gene may change as a result of host-specific adaptive alterations of protein functionality or host-specific immune-mediated selection. We present a codon-based model that attempts to include these effects by allowing the position-specific substitution process to change in conjunction with a host change event. Following maximum-likelihood parameter estimation, we employ an empirical Bayesian procedure to identify candidate sites potentially involved in host-specific adaptation. We discuss the applicability of the model to the more general problem of ascertaining whether the selective regime differs in two groups of related organisms. The utility of the model is illustrated on a data set of nucleoprotein sequences from the influenza A virus obtained from avian and human hosts.

Key Words: host-specific adaptation • influenza evolution • codon model


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