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Molecular Biology and Evolution 19:1633-1636 (2002)
© 2002 Society for Molecular Biology and Evolution

Molecular Evolution of Functional Genes on the Mammalian Y Chromosome

Gerald J. Wyckoff*, Joyce Li{dagger} and Chung-I Wu{ddagger}

*Department of Human Genetics,
{dagger}The Laboratory School,
{ddagger}Department of Ecology and Evolution, The University of Chicago

The first 150 words of the full text of this article appear below.

The dimorphic sex chromosomes likely evolved from a pair of autosomes, followed by Y-chromosome degeneracy and X-chromosome dosage compensation (Ohno 1967Citation ). The Y-linked genes generally degenerate by the processes of Muller's ratchet, genetic hitchhiking, or background selection after it has ceased to recombine with the X chromosome (Bachtrog and Charlesworth 2002Citation ). There remain, however, several functional genes on the Y chromosome outside of the pseudoautosomal region (Lahn and Page 1997Citation ). We wish to know whether the processes that contribute to Y-degeneracy also leave a mark on these functional genes. Furthermore, there is often a degree of functional divergence between the X- and Y-linked genes. When genes are evolving toward new functions, the rate of amino acid substitutions is expected to be high during the initial phase of divergence and eventually returns to a lower rate of evolution (Ohno 1970Citation ; Li 1982Citation ; Lynch and Conery 2000Citation . . . [Full Text of this Article]


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