Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (8)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Gaucher, E. A.
Right arrow Articles by Benner, S. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Gaucher, E. A.
Right arrow Articles by Benner, S. A.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Molecular Biology and Evolution 19:569-573 (2002)
© 2002 Society for Molecular Biology and Evolution

The Crystal Structure of eEF1A Refines the Functional Predictions of an Evolutionary Analysis of Rate Changes Among Elongation Factors

Eric A. Gaucher, Ujjwal K. Das, Michael M. Miyamoto and Steven A. Benner

*NASA Astrobiology Institute, Department of Chemistry
{dagger}Department of Zoology, University of Florida

The complex interplay between sequence, folded structure, and function in a divergently evolving protein family can be reflected in the rate at which individual sites accumulate amino acid replacements. Thus, detecting shifts in the evolutionary rates of individual sites offers a way to identify potential instances of functional divergence among proteins (Benner 1989Citation ; Naylor and Gerstein 2000Citation ; Gaucher, Miyamoto, and Benner 2001Citation ; Marin et al. 2001Citation ; Wang and Gu 2001Citation ). The covarion model of Fitch and Markowitz (1970)Citation was among the first to consider protein structure and function in this way. The ability to detect rate-shift sites relies on molecular evolutionary approaches (Gu 1999, 2001Citation ; Benner and Gaucher 2001Citation ; Galtier 2001Citation ; Landgraf, Xenarios, and Eisenberg 2001Citation ), whereas functional explanations for these changes can be derived from experiments in structural biology (Golding and Dean 1998Citation ). This combination defines a powerful approach . . . [Full Text of this Article]

Acknowledgements

Footnotes

References


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 GENES CELLSHome page
K. Koiwai, S. Maezawa, T. Hayano, M. Iitsuka, and O. Koiwai
BPOZ-2 directly binds to eEF1A1 to promote eEF1A1 ubiquitylation and degradation and prevent translation.
Genes Cells, June 1, 2008; 13(6): 593 - 607.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
P. J. Keeling and Y. Inagaki
A class of eukaryotic GTPase with a punctate distribution suggesting multiple functional replacements of translation elongation factor 1{alpha}
PNAS, October 26, 2004; 101(43): 15380 - 15385.
[Abstract] [Full Text] [PDF]

Home page
 Mol Biol EvolHome page
S. Gribaldo, D. Casane, P. Lopez, and H. Philippe
Functional Divergence Prediction from Evolutionary Analysis: A Case Study of Vertebrate Hemoglobin
Mol. Biol. Evol., November 1, 2003; 20(11): 1754 - 1759.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
Y. Inagaki, C. Blouin, E. Susko, and A. J. Roger
Assessing functional divergence in EF-1{alpha} and its paralogs in eukaryotes and archaebacteria
Nucleic Acids Res., July 15, 2003; 31(14): 4227 - 4237.
[Abstract] [Full Text] [PDF]