Molecular Biology and Evolution 18:1134-1135 (2001)
© 2001 Society for Molecular Biology and Evolution
LETTER |
Coalescent Simulations and Statistical Tests of Neutrality
Department of Ecology and Evolution, University of Chicago
Recently, Depaulis and Veuille (1998)
proposed two new test statistics based on the number and frequency of different haplotypes. In a companion letter, Markovtsova, Marjoram, and Tavaré (2001) point out that Depaulis and Veuille (1998)
do not use the standard implementation for their coalescent simulations. Standard coalescent simulations first produce random genealogies, then place mutations at constant rate 
/2 ( = 4Nµ is the population mutation parameter, where N is the effective population size and µ is the per-locus mutation rate per generation) along each of the branches (Kingman 1982a, 1982b
; Hudson 1990
). Instead, Depaulis and Veuille (1998)
generate distributions for their statistics by
Acknowledgements
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