Molecular Biology and Evolution 18:1045-1056 (2001)
© 2001 Society for Molecular Biology and Evolution
ARTICLE |
Changes in the Recombinational Environment Affect Divergence in the yellow Gene of Drosophila
Departament de Genètica, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain
The complete coding region of the yellow (y) gene was sequenced in different Drosophila species. In the species of the melanogaster subgroup (D. melanogaster, D. simulans, D. mauritiana, D. yakuba, and D. erecta), this gene is located at the tip of the X chromosome in a region with a strong reduction in recombination rate. In contrast, in D. ananassae (included in the ananassae subgroup of the melanogaster group) and in the obscura group species (D. subobscura, D. madeirensis, D. guanche, and D. pseudoobscura), the y gene is located in regions with normal recombination rates. As predicted by the hitchhiking and background selection models, this change in the recombinational environment affected synonymous divergence in the y-gene-coding region. Estimates of the number of synonymous substitutions per site were much lower between the obscura group species and D. ananassae than between the species of the obscura group and the melanogaster subgroup. In fact, a highly significant increase in the rate of synonymous substitution was detected in all lineages leading to the species of the melanogaster subgroup relative to the D. ananassae lineage. This increase can be explained by a higher fixation rate of mutations from preferred to unpreferred codons (slightly deleterious mutations). The lower codon bias detected in all species of the melanogaster subgroup relative to D. ananassae (or to the obscura group species) would be consistent with this proposal. Therefore, at least in Drosophila, changes in the recombination rate in different lineages might cause deviations of the molecular-clock hypothesis and contribute to the overdispersion of the rate of synonymous substitution. In contrast, the change in the recombinational environment of the y gene has no detectable effect on the rate of amino acid replacement in the Yellow protein.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  R. Nielsen, V. L. Bauer DuMont, M. J. Hubisz, and C. F. Aquadro Maximum Likelihood Estimation of Ancestral Codon Usage Bias Parameters in Drosophila Mol. Biol. Evol., January 1, 2007; 24(1): 228 - 235. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W.-Y. Ko, S. Piao, and H. Akashi Strong Regional Heterogeneity in Base Composition Evolution on the Drosophila X Chromosome Genetics, September 1, 2006; 174(1): 349 - 362. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Akashi, W.-Y. Ko, S. Piao, A. John, P. Goel, C.-F. Lin, and A. P. Vitins Molecular Evolution in the Drosophila melanogaster Species Subgroup: Frequent Parameter Fluctuations on the Timescale of Molecular Divergence Genetics, March 1, 2006; 172(3): 1711 - 1726. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. R. Morris, D. A. Petrov, A. M. Lee, and C.-t. Wu Enhancer Choice in Cis and in Trans in Drosophila melanogaster: Role of the Promoter Genetics, August 1, 2004; 167(4): 1739 - 1747. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. B. DuMont, J. C. Fay, P. P. Calabrese, and C. F. Aquadro DNA Variability and Divergence at the Notch Locus in Drosophila melanogaster and D. simulans: A Case of Accelerated Synonymous Site Divergence Genetics, May 1, 2004; 167(1): 171 - 185. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Zhang and H. Kishino Genomic Background Predicts the Fate of Duplicated Genes: Evidence From the Yeast Genome Genetics, April 1, 2004; 166(4): 1995 - 1999. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Zhang and H. Kishino Genomic Background Drives the Divergence of Duplicated Amylase Genes at Synonymous Sites in Drosophila Mol. Biol. Evol., February 1, 2004; 21(2): 222 - 227. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Perez, A. Munte, J. Rozas, C. Segarra, and M. Aguade Nucleotide Polymorphism in the RpII215 Gene Region of the Insular Species Drosophila guanche: Reduced Efficacy of Weak Selection on Synonymous Variation Mol. Biol. Evol., November 1, 2003; 20(11): 1867 - 1875. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Hey and R. M. Kliman Interactions Between Natural Selection, Recombination and Gene Density in the Genes of Drosophila Genetics, February 1, 2002; 160(2): 595 - 608. [Abstract] [Full Text] [PDF]
|
|