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Molecular Biology and Evolution 18:750-756 (2001)
© 2001 Society for Molecular Biology and Evolution

ARTICLE

Structural Constraints and Emergence of Sequence Patterns in Protein Evolution

Gustavo Parisi and Julián Echave,

Universidad Nacional de Quilmes, Bernal, Argentina

The aim of this work was to study the relationship between structure conservation and sequence divergence in protein evolution. To this end, we developed a model of structurally constrained protein evolution (SCPE) in which trial sequences, generated by random mutations at gene level, are selected against departure from a reference three-dimensional structure. Since at the mutational level SCPE is completely unbiased, any emergent sequence pattern will be due exclusively to structural constraints. In this first report, it is shown that SCPE correctly predicts the characteristic hexapeptide motif of the left-handed parallel ß helix (LßH) domain of UDP-N-acetylglucosamine acyltransferases (LpxA).


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