Molecular Biology and Evolution 18:384-392 (2001)
© 2001 Society for Molecular Biology and Evolution
ARTICLE |
Mobile Elements and the Genesis of Microsatellites in Dipterans
Department of Ecology and Evolutionary Biology, Princeton University
Factors that influence the genesis and genomic distribution of microsatellite DNA are poorly understood. We have identified a novel class of Dipteran mobile elements, mini-me elements, which help elucidate both of these issues. These retroposons contain two internal proto-microsatellite regions that commonly expand into lengthy microsatellite repeats. These elements are highly abundant, accounting for approximately 1.2% of the Drosophila melanogaster genome, giving them the potential to be a prolific source of microsatellite DNA variation. They also give us the opportunity to observe the outcomes of multiple microsatellite genesis events (initiating from the same proto-microsatellite) at separate mini-me loci. Based on these observations, we determined that the genesis of microsatellites within mini-me elements occurs through two separate mutational processes: the expansion of preexisting tandem repeats and the conversion of sequence with high cryptic simplicity into tandemly repetitive DNA. These modes of microsatellite genesis can be generalized beyond the case of mini-me elements and help to explain the genesis of microsatellites in any sequence region that is not constrained by selection.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  E. W. Chambers, J. K. Meece, J. A. McGowan, D. D. Lovin, R. R. Hemme, D. D. Chadee, K. McAbee, S. E. Brown, D. L. Knudson, and D. W. Severson Microsatellite Isolation and Linkage Group Identification in the Yellow Fever Mosquito Aedes aegypti J. Hered., May 1, 2007; 98(3): 202 - 210. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Malysheva, O. N. Tokarskaya, V. G. Petrosyan, F. D. Danielyan, I. S. Darevsky, and A. P. Ryskov Genomic Variation in Parthenogenetic Lizard Darevskia armeniaca: Evidence from DNA Fingerprinting Data J. Hered., April 13, 2007; (2007) esm003v2. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Archak, E. Meduri, P. S. Kumar, and J. Nagaraju InSatDb: a microsatellite database of fully sequenced insect genomes Nucleic Acids Res., January 12, 2007; 35(suppl_1): D36 - D39. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Richards, Y. Liu, B. R. Bettencourt, P. Hradecky, S. Letovsky, R. Nielsen, K. Thornton, M. J. Hubisz, R. Chen, R. P. Meisel, et al. Comparative genome sequencing of Drosophila pseudoobscura: Chromosomal, gene, and cis-element evolution Genome Res., January 1, 2005; 15(1): 1 - 18. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Perez, F. Cruz, and P. Presa Distribution Properties of Polymononucleotide Repeats in Molluscan Genomes J. Hered., January 1, 2005; 96(1): 40 - 51. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Negre, J. M. Ranz, F. Casals, M. Caceres, and A. Ruiz A New Split of the Hox Gene Complex in Drosophila: Relocation and Evolution of the Gene labial Mol. Biol. Evol., December 1, 2003; 20(12): 2042 - 2054. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. L. Ross, K. A. Dyer, T. Erez, S. J. Miller, J. Jaenike, and T. A. Markow Rapid Divergence of Microsatellite Abundance Among Species of Drosophila Mol. Biol. Evol., July 1, 2003; 20(7): 1143 - 1157. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. Holyoake and M. G. Kidwell Vege and Mar: Two Novel hAT MITE Families from Drosophila willistoni Mol. Biol. Evol., February 1, 2003; 20(2): 163 - 167. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. G. Kidwell and A. J. Holyoake Transposon-Induced Hotspots for Genomic Instability Genome Res., August 1, 2001; 11(8): 1321 - 1322. [Full Text] [PDF]
|
|