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Molecular Biology and Evolution 18:266-270 (2001)
© 2001 Society for Molecular Biology and Evolution

LETTER

Ty3/Gypsy Retrotransposon Fossils in Mammalian Genomes: Did They Evolve into New Cellular Functions?

Jean-Nicolas Volff, Cornelia Körting and Manfred Schartl

Physiologische Chemie I, Biozentrum, University of Würzburg, Würzburg, Germany

Long-terminal-repeat (LTR) retrotransposons from the Ty3/Gypsy superfamily have been detected in various eukaryotic taxa, including some vertebrate lineages (lampreys, bony fishes, amphibians, and reptiles; Miller et al. 1999Citation and references therein). Nevertheless, molecular and database screenings failed to detect such elements in the genome of mammals. Considering the huge amount of sequence information available on mammalian genomes and transcriptomes, this suggested that Ty3/Gypsy retrotransposons either have been lost or are present at an extremely low copy number in mammals.

By examination of public sequence databases, we identified Ty3/Gypsy-like sequences in mammals. The human protein KIAA1051, obtained from a brain cDNA library (Kikuno et al. 1999Citation ), shows significant similarities to the Gag structural core protein of some Ty3/Gypsy retrotransposons from the Ty3 family, including Sushi from the pufferfish Fugu rubripes (Poulter and Butler 1998Citation ) (42.5% similarities, expected value E = . . . [Full Text of this Article]

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