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Molecular Biology and Evolution 17:416-422 (2000)
© 2000 Society for Molecular Biology and Evolution

Articles

Strand Symmetry Around the ß-Globin Origin of Replication in Primates

M. Pilar Francino* and Howard Ochman,*{dagger}

*Department of Biology, University of Rochester; and
{dagger}Department of Ecology and Evolutionary Biology, University of Arizona

Certain mutations are known to occur with differing frequencies on the leading and lagging strands of DNA. The extent to which these mutational biases affect the sequences of higher eukaryotes has been difficult to ascertain because the positions of most replication origins are not known, making it impossible to distinguish between the leading and lagging strands. To resolve whether strand biases influence the evolution of primate sequences, we compared the substitution patterns in noncoding regions adjacent to an origin of replication identified within the ß-globin complex. Although there was limited asymmetry around the ß-globin origin of replication, patterns of substitutions do not support the existence of a mutational bias between the leading and lagging strands of chromosomal DNA replication in primates.


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