Molecular Biology and Evolution, Vol 15, 1269-1274, Copyright © 1998 by Society for Molecular Biology and Evolution
C Schlotterer, R Ritter, B Harr and G Brem
Within recent years, microsatellite have become one of the most powerful
genetic markers in biology. For several mammalian species, microsatellite
mutation rates have been estimated on the order of 10(- 3)-10(-5). A recent
study, however, demonstrated mutation rates in Drosophila melanogaster of
at least one order of magnitude lower than those in mammals. To further
test this result, we examined mutation rates of different microsatellite
loci using a larger sample size. We screened 24 microsatellite loci in 119
D. melanogaster lines maintained for approximately 250 generations and
detected 9 microsatellite mutations. The average mutation rate of 6.3 x
10(-6) is identical to the mutation rate from a previous study. Most
interestingly, all nine mutations occurred at the same allele of one locus
(DROYANETSB). This hypermutable allele has 28 dinucleotide repeats and is
among the longest microsatellite reported in D. melanogaster. The
allele-specific mutation rate of 3.0 x 10(-4) per generation is within the
range of mammalian mutation rates. Future microsatellite analyses will have
to account for the dramatic differences in allele-specific mutation rates.
ORIGINAL ARTICLE
High mutation rate of a long microsatellite allele in Drosophila melanogaster provides evidence for allele-specific mutation rates
Institut fur Tierzucht und Genetik, Vienna, Austria. christian.schloetterer@vu-wien.ac.at
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