Molecular Biology and Evolution, Vol 14, 854-860, Copyright © 1997 by Society for Molecular Biology and Evolution
H Ellegren, S Moore, N Robinson, K Byrne, W Ward and BC Sheldon
The application of microsatellites in evolutionary studies requires an
understanding of the patterns governing their evolution in different
species. The finding that homologous microsatellite loci are longer, i.e.,
containing more repeat units, in human and in other primates has been taken
as evidence for directional microsatellite evolution and for a difference
in the rate of evolution between species. However, it has been argued that
this finding is an inevitable consequence of biased selection of
longer-than-average microsatellites in human, because cloning procedures
are adopted to generate polymorphic and, hence, long markers. As a test of
this hypothesis, we conducted a reciprocal comparison of the lengths of
microsatellite loci in cattle and sheep using markers derived from the
bovine genome as well as the ovine genome. In both cases, amplification
products were longer in the focal species, and loci were also more
polymorphic in the species from which they were originally cloned. The
crossing pattern that we found suggests that interspecific length
differences detected at homologous microsatellite loci are the result of
biased selection of loci associated with cloning procedures. Hence,
comparisons of microsatellite evolution between species are flawed unless
they are based on reciprocal analyses or on genuinely random selection of
loci with respect to repeat length.
ORIGINAL ARTICLE
Microsatellite evolution--a reciprocal study of repeat lengths at homologous loci in cattle and sheep
Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Uppsala. hans.ellegren@bmc.uu.se
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