Molecular Biology and Evolution, Vol 14, 602-610, Copyright © 1997 by Society for Molecular Biology and Evolution
AC Drew and PJ Brindley
The genomes of representative species of fishes, amphibians, and reptiles
contain non-long-terminal-repeat (non-LTR) retrotransposons showing strong
sequence identity to the chicken repeat 1 (CR1) non-LTR retrotransposon
from birds. These nonavian retroelements have been termed CR1-like
elements. We have isolated sequences of a non-LTR retrotransposon from the
human blood fluke Schistosoma mansoni. These schistosome sequences, which
we have termed the SR1 family of non-LTR retrotransposons, contain regions
of deduced amino acids characteristic of the CR1-like elements. SR1
elements possess atypical 3' termini consisting of the tandem repeat
(AACCATTTG)2 which are similar in structure to the imperfect tandem repeat
of the 3' termini of CR1. There are at least 200 copies of SR1 interspersed
through the genome of S. mansoni. The structural and amino acid sequence
similarities of SR1 with members of the CR1-like elements suggest that the
SR1 family belongs to the CR1-like category of non-LTR retrotransposons.
Although other non-LTR retrotransposons have been described in
invertebrates, this is the first CR1-like element reported from a
nonvertebrate taxon, suggesting that the phylogenetic distribution of
CR1-like retrotransposons is not restricted to vertebrates.
ORIGINAL ARTICLE
A retrotransposon of the non-long terminal repeat class from the human blood fluke Schistosoma mansoni. Similarities to the chicken-repeat-1- like elements of vertebrates
Molecular Parasitology Unit, Queensland Institute of Medical Research, Australia.
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