Molecular Biology and Evolution, Vol 12, 938-943, Copyright © 1995 by Society for Molecular Biology and Evolution
A Popadic, D Popadic and WW Anderson
During the last 60 years, the inversion polymorphism on the third
chromosome of Drosophila pseudoobscura has become a case study of the
evolution of linked blocks of genes, isolated from each other by the
suppression of recombination in heterozygotes for different inversions. Due
to its location within inverted regions in most gene arrangements, the
amylase (Amy) gene region can be used to elucidate the molecular pattern of
evolution in these inversions. We studied this region in the Tree Line
phylad of gene arrangements, with regard to both restriction site
polymorphisms (RSP) and nucleotide sequences. The analysis of restriction
maps, encompassing 26 kb, corroborates the cytogenetic phylogeny
established on the basis of inversion breakpoints. However, we found that
the 2.7 kb of nucleotide sequences of the AmyI gene are identical in both
Estes Park and Hidalgo arrangements, despite the fact that these inversions
arose independently from Tree Line. These contrasting results suggest that
a homogenizing force, most likely gene conversion, is able to bring about
localized exchanges between otherwise isolated gene arrangements.
ORIGINAL ARTICLE
Interchromosomal exchange of genetic information between gene arrangements on the third chromosome of Drosophila pseudoobscura
Department of Genetics, University of Georgia, Athens 30602-7223, USA.
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