Molecular Biology and Evolution, Vol 10, 539-551, Copyright © 1993 by Society for Molecular Biology and Evolution
K Kuma, N Iwabe and T Miyata
Immunoglobulin (Ig)-, fibronectin type III (FN-III)-, and cadherin- related
sequences are often found in multiple repeats in the extracellular regions
of various cell adhesion molecules. The amino acid sequences of 82
different cadherin-like repeats from 13 known members of the cadherin
superfamily were compared for six highly conserved regions, and a frequency
matrix represented as amino acids versus position matrix was calculated
based on the alignment. With the frequency matrix, further members of the
cadherin superfamily were searched for in the protein data base. It was
found that the ret protein, a receptor-type-protein tyrosine kinase,
contains cadherin- like repeats in the extracellular region. A similar
analysis was also carried out for the FN-III superfamily. Nine
receptor-type-protein tyrosine kinases were shown to exhibit significant
similarities, in terms of sequence, with known FN-III-like repeats. Several
receptor- type-protein tyrosine kinases have already been reported to have
Ig- like repeats in their extracellular regions. Thus these receptor-type-
protein tyrosine kinases--together with the remaining receptors, whose
structures are not yet characterized--may be classified into at least four
distinct groups based on the structural differences in the extracellular
domains. A molecular phylogenetic tree inferred from the shared kinase
domains of these receptor-type-protein tyrosine kinases revealed a close
relationship between the branching patterns and the grouping based on the
structural differences of the extracellular region.
ORIGINAL ARTICLE
Motifs of cadherin- and fibronectin type III-related sequences and evolution of the receptor-type-protein tyrosine kinases: sequence similarity between proto-oncogene ret and cadherin family
Department of Biology, Kyushu University, Japan.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  M. Hahn and J. M. Bishop Expression pattern of Drosophila ret suggests a common ancestral origin between the metamorphosis precursors in insect endoderm and the vertebrate enteric neurons PNAS, January 10, 2001; (2001) 21558598. [Abstract] [Full Text]
|
|
|
|
 |
|
 D. H. J. van Weering, T. C. Moen, I. Braakman, P. D. Baas, and J. L. Bos Expression of the Receptor Tyrosine Kinase Ret on the Plasma Membrane Is Dependent on Calcium J. Biol. Chem., May 15, 1998; 273(20): 12077 - 12081. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Gattei, A. Celetti, A. Cerrato, M. Degan, A. De Iuliis, F. M. Rossi, G. Chiappetta, C. Consales, S. Improta, V. Zagonel, et al. Expression of the RET Receptor Tyrosine Kinase and GDNFR-alpha in Normal and Leukemic Human Hematopoietic Cells and Stromal Cells of the Bone Marrow Microenvironment Blood, April 15, 1997; 89(8): 2925 - 2937. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Hahn and J. M. Bishop Expression pattern of Drosophila ret suggests a common ancestral origin between the metamorphosis precursors in insect endoderm and the vertebrate enteric neurons PNAS, January 30, 2001; 98(3): 1053 - 1058. [Abstract] [Full Text] [PDF]
|
|