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Molecular Biology and Evolution 19:1395-1398 (2002)
© 2002 Society for Molecular Biology and Evolution

Is the Synonymous Substitution Rate in Mammals Gene-Specific?

Elizabeth J. B. Williams and Laurence D. Hurst

Department of Biology and Biochemistry, University of Bath, Claverton Down, United Kingdom

The first 150 words of the full text of this article appear below.

There is a great deal of variation in silent rates of evolution (Ks) between genes in the same species pair comparison (Bernardi, Mouchiroud, and Gautier 1993Citation ; Wolfe and Sharp 1993Citation ; Mouchiroud, Gautier, and Bernardi 1995Citation ). This may represent random fluctuation (Kumar and Subramanian 2002Citation ) or may be deterministically caused. Evidence for the latter comes from the finding that the rate of silent site evolution of a gene is repeatable across independent lineages (Bulmer, Wolfe, and Sharp 1991Citation ; Mouchiroud, Gautier, and Bernardi 1995Citation ; Bielawski, Dunn, and Yang 2000Citation ). Most notably, Mouchiroud, Gautier, and Bernardi (1995)Citation found that the number of synonymous substitutions per synonymous site (Ks) for a gene in the human-cow comparison was a very strong predictor of the Ks of the same gene in the mouse-rat comparison.

This repeatability has been used as evidence (Mouchiroud, Gautier, and Bernardi 1995Citation ) for selection . . . [Full Text of this Article]


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