Molecular Biology and Evolution 19:964-967 (2002)
© 2002 Society for Molecular Biology and Evolution
The Relative Abundance of Dinucleotides in Transposable Elements in Five Species
*Laboratoire Biométrie et Biologie Évolutive, UMR CNRS 5558, Université Lyon 1, 69622 Villeurbanne Cedex, France;
Laboratoire Populations, Génétique et Évolution, UPR CNRS 9034, 91198 Gif/Yvette Cedex, France
Burge, Campbell, and Karlin (1992)
observed that the relative frequencies of di- and trinucleotides characterize a genome, independent of its base composition and the coding and noncoding capacity of the regions analyzed. Species thus differ with regard to this genomic signature, which is constant in a given genome and shows similarities between related species (Gentles and Karlin 2001
). The variation in the relative abundance of dinucleotides is interpreted as reflecting differences between species in the cellular machinery for replication and repair, which may select specific dinucleotides in the sequence (Campbell, Mrázek, and Karlin 1999
). A tendency toward the suppression of CG is often observed and is interpreted as resulting from the action of methylation activities (Bird 1986
). The dinucleotides pattern of the mitochondrial genome has also been shown to differ from that of the nuclear genome, and the explanation suggests that nuclear and mitochondrial genomes use independent
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