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Molecular Biology and Evolution 19:2026-2029 (2002)
© 2002 Society for Molecular Biology and Evolution

5' Genomic Structure of Human Sp3

Marjorie F. Oleksiak and Douglas L. Crawford

School of Biological Sciences, University of Missouri–Kansas City

The first 150 words of the full text of this article appear below.

Comparative sequence analysis among evolutionarily related genes can provide better insights into gene structures and functions compared with methods that rely solely on canonical rules (e.g., open reading frames, intron positions, or Kozak sequences). Presented here is a comparative sequence analysis of human Sp3 that provides the missing N-terminal portion.

Evolutionarily, the transcription factors Sp1 and Sp3 are related more closely to each other than to other members of the Sp family (Kolell and Crawford 2002), and numerous studies have examined the roles of Sp1 and Sp3 in transcriptional regulation. The Sp transcription factor family members interact with general transcriptional machinery, cell cycle regulators such as retinoblastoma protein, and other transcription factors (Pugh and Tjian 1990Citation ; Seto, Lewis, and Shenk 1993Citation ; Gill et al. 1994Citation ; Udvadia, Templeton, and Horowitz 1995Citation ; Kennett, Moorefield, and Horowitz 2002Citation ). Sp3 and Sp1 belong to this family of transcription factors . . . [Full Text of this Article]


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A. Sapetschnig, F. Koch, G. Rischitor, T. Mennenga, and G. Suske
Complexity of Translationally Controlled Transcription Factor Sp3 Isoform Expression
J. Biol. Chem., October 1, 2004; 279(40): 42095 - 42105.
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