Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (11)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Wildman, D. E.
Right arrow Articles by Grossman, L. I.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Wildman, D. E.
Right arrow Articles by Grossman, L. I.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Molecular Biology and Evolution 19:1812-1815 (2002)
© 2002 Society for Molecular Biology and Evolution

Episodic Positive Selection in Ape Cytochrome c Oxidase Subunit IV

Derek E. Wildman*, Wei Wu*, Morris Goodman*{dagger} and Lawrence I. Grossman*

*Center for Molecular Medicine and Genetics
{dagger}Department of Anatomy and Cell Biology, Wayne State University School of Medicine

The first 150 words of the full text of this article appear below.

Periods of elevated rates of nonsynonymous nucleotide substitutions for electron transport chain (ETC) genes have occurred during the evolution of anthropoid primates (New World monkeys, Old World monkeys, apes, and humans) (Grossman et al. 2001Citation ). Given the vital role the ETC genes play in energy metabolism, and the coadaptive evolution apparently undergone by the holoenzymes of cytochrome bc1 (Complex III) and cytochrome c oxidase (Complex IV) in anthropoid primates (Andrews and Easteal 2000Citation ; Grossman et al. 2001Citation ; Schmidt et al. 2001Citation ), it is likely that positive selection rather than reduction of functional constraints is the cause of the elevated nonsynonymous substitution rates. ETC genes that have been identified as having undergone periods of positive selection in anthropoid primates are cytochromes b and c (CYB, CYC) and the Complex IV genes COX1, COX2, cytochrome c oxidase subunit IV ubiquitous isoform (COX4-1),1 and COX7AH . . . [Full Text of this Article]


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Proc. Natl. Acad. Sci. USAHome page
T. R. Schmidt, D. E. Wildman, M. Uddin, J. C. Opazo, M. Goodman, and L. I. Grossman
Rapid electrostatic evolution at the binding site for cytochrome c on cytochrome c oxidase in anthropoid primates
PNAS, May 3, 2005; 102(18): 6379 - 6384.
[Abstract] [Full Text] [PDF]

Home page
 Mol Biol EvolHome page
M. P. Bayona-Bafaluy, S. Muller, and C. T. Moraes
Fast Adaptive Coevolution of Nuclear and Mitochondrial Subunits of ATP Synthetase in Orangutan
Mol. Biol. Evol., March 1, 2005; 22(3): 716 - 724.
[Abstract] [Full Text] [PDF]

Home page
 Mol Biol EvolHome page
T.-K. Seo, H. Kishino, and J. L. Thorne
Estimating Absolute Rates of Synonymous and Nonsynonymous Nucleotide Substitution in Order to Characterize Natural Selection and Date Species Divergences
Mol. Biol. Evol., July 1, 2004; 21(7): 1201 - 1213.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
M. Uddin, D. E. Wildman, G. Liu, W. Xu, R. M. Johnson, P. R. Hof, G. Kapatos, L. I. Grossman, and M. Goodman
Sister grouping of chimpanzees and humans as revealed by genome-wide phylogenetic analysis of brain gene expression profiles
PNAS, March 2, 2004; 101(9): 2957 - 2962.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
A. Goldberg, D. E. Wildman, T. R. Schmidt, M. Huttemann, M. Goodman, M. L. Weiss, and L. I. Grossman
Adaptive evolution of cytochrome c oxidase subunit VIII in anthropoid primates
PNAS, May 13, 2003; 100(10): 5873 - 5878.
[Abstract] [Full Text] [PDF]