Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow An erratum has been published
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (6)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Seixas, S.
Right arrow Articles by Rocha, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Seixas, S.
Right arrow Articles by Rocha, J.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Molecular Biology and Evolution 19:1802-1806 (2002)
© 2002 Society for Molecular Biology and Evolution

Microsatellite Variation and Evolution of the Human Duffy Blood Group Polymorphism

Susana Seixas*,{dagger}, Nuno Ferrand{dagger},{ddagger} and Jorge Rocha*,{dagger}

*Instituto de Patologia e Imunologia Molecular da Universidade do Porto (IPATIMUP), R. Dr. Roberto Frias s/n, Porto, Portugal;
{dagger}Faculdade de Ciências, Universidade do Porto, Portugal;
{ddagger}Centro de Estudos de Ciência Animal (CECA), ICETA, Universidade do Porto, Portugal

The first 150 words of the full text of this article appear below.

The human Duffy blood group (FY) antigens are transmembrane glycoproteins that function as receptors for chemokines and for the malarial parasite Plasmodium vivax (reviewed in Hadley and Peiper 1997Citation ). Most of the FY antigenic variation is determined by three common alleles (FY*A, FY*B, and FY*O) in a gene located on chromosome 1q21-q22. DNA sequence characterization of these alleles and interspecies comparisons with the orthologous genes from nonhuman primates have shown that FY*A and FY*O are derived variants, each resulting from a single mutation in an ancestral FY*B background (Chaudhuri et al. 1995Citation ; Tourmamille et al. 1995Citation ). Whereas the FY*A gene product is a functional protein with a Gly44Asp substitution, FY*O has a T-46C promoter mutation that disrupts a binding site for the GATA1 erythroid transcription factor leading to a tissue-specific loss of expression of FY antigens in red blood cells (Tourmamille et al. 1995Citation ). In contrast . . . [Full Text of this Article]

Supplementary Material


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Mol Biol EvolHome page
S. Seixas, G. Suriano, F. Carvalho, R. Seruca, J. Rocha, and A. Di Rienzo
Sequence Diversity at the Proximal 14q32.1 SERPIN Subcluster: Evidence for Natural Selection Favoring the Pseudogenization of SERPINA2
Mol. Biol. Evol., February 1, 2007; 24(2): 587 - 598.
[Abstract] [Full Text] [PDF]

Home page
 Mol Biol EvolHome page
J. Mu, D. A. Joy, J. Duan, Y. Huang, J. Carlton, J. Walker, J. Barnwell, P. Beerli, M. A. Charleston, O. G. Pybus, et al.
Host Switch Leads to Emergence of Plasmodium vivax Malaria in Humans
Mol. Biol. Evol., August 1, 2005; 22(8): 1686 - 1693.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
A. A. Escalante, O. E. Cornejo, D. E. Freeland, A. C. Poe, E. Durrego, W. E. Collins, and A. A. Lal
A monkey's tale: The origin of Plasmodium vivax as a human malaria parasite
PNAS, February 8, 2005; 102(6): 1980 - 1985.
[Abstract] [Full Text] [PDF]