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Molecular Biology and Evolution 18:1823-1827 (2001)
© 2001 Society for Molecular Biology and Evolution

Traditional Phylogenetic Reconstruction Methods Reconstruct Shallow and Deep Evolutionary Relationships Equally Well

Michael S. Rosenberg and Sudhir Kumar

Department of Biology, Arizona State University

The wealth of data available for molecular phylogenetic analyses is expanding at an exponential pace. As data sets have become larger, it has become increasingly critical to understand the advantages and disadvantages of using various phylogenetic inference methods. Four inference methods based on three optimization criteria are commonly used to reconstruct evolutionary history from molecular data: neighbor joining (NJ), minimum evolution (ME), maximum parsimony (MP), and maximum likelihood (ML). The overall efficiency and performance of these methods in reconstructing the true tree is known to vary with substitution rate, transition-transversion ratio, and sequence divergence (Miyamoto and Cracraft 1991Citation ; Nei and Kumar 2000Citation ).

Computer simulation has proven to be an excellent means of assessing the performance of tree-building methods (reviewed in Nei and Kumar 2000Citation , chapter 9). It can be used to examine the overall performance of a method or specific aspects of its performance (e.g., Hillis 1996Citation . . . [Full Text of this Article]

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