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Molecular Biology and Evolution 18:1601-1603 (2001)
© 2001 Society for Molecular Biology and Evolution

Sex-Chromosomal Differentiation and Amelogenin Genes in Mammals

Mineyo Iwase, Yoko Satta and Naoyuki Takahata

Department of Biosystems Science, Graduate University for Advanced Studies, Hayama, Kanagawa, Japan

Paralogous gene pairs on the mammalian sex chromosomes can provide useful information on the tempo and mode of X-Y differentiation. Recently, Lahn and Page (1999)Citation reported intriguing results on the chromosomal locations and synonymous sequence divergences (ks with multiple-hit correction) of 19 pairs of X-Y-paralogous cDNA sequences in humans or squirrel monkeys. It was found that there are four distinct groups (strata) of the gene pairs in terms of the ks value. Of these, seven belong to stratum 4, and the X paralogs are clustered in a single chromosomal region which is adjacent to the pseudoautosomal boundary in the short arm of chromosome X. In contrast, the seven Y paralogs are scattered on chromosome Y, presumably owing to frequent chromosomal rearrangements. Together with similar observations on strata 1, 2, and 3, it was hypothesized that X-Y-chromosomal differentiation was initiated one stratum at a time and that stratum 1 was . . . [Full Text of this Article]

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