Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (10)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Lloréns, C.
Right arrow Articles by Marín, I.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lloréns, C.
Right arrow Articles by Marín, I.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Molecular Biology and Evolution 18:1597-1600 (2001)
© 2001 Society for Molecular Biology and Evolution

A Mammalian Gene Evolved from the Integrase Domain of an LTR Retrotransposon

Carlos Lloréns and Ignacio Marín

Departamento de Genética and Instituto Cavanilles de Biodiversidad y Biología Evolutiva, Universidad de Valencia, Spain

Ty3/Gypsy long-terminal-repeat (LTR) retrotransposons are among the best-known transposable elements. They inhabit the genomes of many eukaryotic organisms, such as slime molds, plants, fungi, and animals, including vertebrates (Xiong and Eickbush 1990Citation ; Malik and Eickbush 1999Citation ; Miller et al. 1999Citation ; Marín and Lloréns 2000Citation ). However, in spite of extensive genomic information, these elements had never been found in mammals. In the process of building a database of integrase domain (IN) sequences, we found an intriguing human sequence very similar to the IN of Ty3/Gypsy elements. It was particularly similar to the IN of the Drosophila melanogaster 412 element (E value = 10-27). The sequence of the human gene, which we called Gypsy integrase-1, or Gin-1, was reconstructed by combining information from genomic and cDNA sequences present in the National Center for Biotechnology Information databases (online at http://www.ncbi.nlm.nih.gov/; sequences in TIGR and Sanger Center databases . . . [Full Text of this Article]

Footnotes

References


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Nucleic Acids ResHome page
C. Llorens, R. Futami, D. Bezemer, and A. Moya
The Gypsy Database (GyDB) of mobile genetic elements
Nucleic Acids Res., January 11, 2008; 36(suppl_1): D38 - D46.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
E. M. Zdobnov, Món. Campillos, E. D. Harrington, D. Torrents, and P. Bork
Protein coding potential of retroviruses and other transposable elements in vertebrate genomes
Nucleic Acids Res., February 16, 2005; 33(3): 946 - 954.
[Abstract] [Full Text] [PDF]

Home page
 Mol Biol EvolHome page
E. W. Ganko, V. Bhattacharjee, P. Schliekelman, and J. F. McDonald
Evidence for the Contribution of LTR Retrotransposons to C. elegans Gene Evolution
Mol. Biol. Evol., November 1, 2003; 20(11): 1925 - 1931.
[Abstract] [Full Text] [PDF]