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Molecular Biology and Evolution 18:448-452 (2001)
© 2001 Society for Molecular Biology and Evolution

LETTER

PPP Family of Protein Ser/Thr Phosphatases: Two Distinct Branches?

Alexandra V. Andreeva and Mikhail A. Kutuzov*

*Research School of Biological and Molecular Sciences, Oxford Brookes University, Oxford, England; and
{dagger}Laboratoire de Biophysique Moléculaire et Cellulaire, Département de Biologie Moléculaire et Structurale, Commissariat à l'Energie Atomique-Grenoble, Grenoble, France

All known protein phosphatases specific for phosphorylated Ser and Thr are encoded by two unrelated gene families, termed PPM and PPP (Cohen 1997Citation ; Barford, Das, and Egloff 1998Citation ). The PPM family comprises Mg2+-dependent phosphatases structurally related to PP2C, while the PPP family has traditionally been subdivided into three subfamilies, related to PP1, PP2A, and PP2B (calcineurin). Investigation of these phosphatases has revealed their roles in such processes as glycogen metabolism, regulation of the cell cycle and RNA splicing, regulation of numerous protein kinases, T-cell activation, and memory formation (Cohen 1997Citation ; Klee, Ren, and Wang 1998Citation ; Millward, Zolnierowicz, and Hemmings 1999Citation ; Price and Mumby 1999Citation ; Aggen, Nairn, and Chamberlin 2000Citation ). These three extensively characterized "classical" PPP subfamilies have recently been supplemented by novel members from various species (Cohen 1997Citation ). In addition, a novel divergent group of PPP phosphatases called the PP5/rdgC subfamily . . . [Full Text of this Article]

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