Molecular Biology and Evolution 18:271-275 (2001)
© 2001 Society for Molecular Biology and Evolution
LETTER |
Simple (Wrong) Models for Complex Trees: A Case from Retroviridae
Department of Zoology, Brigham Young University
Although the use of adequate models of evolution should improve the accuracy of phylogenetic inference (Leitner, Kumar, and Albert 1997
; Sullivan and Swofford 1997
; Cunningham, Zhu, and Hillis 1998
), computer simulation studies have shown that under certain circumstances, wrong models can recover the true tree with higher probability than the tree model employed to generate the data (Saitou and Nei 1987
; Schöniger and von Haeseler 1993
; Tajima and Takezaki 1994
; Tateno, Takezaki, and Nei 1994
; Yang 1997a
; Takahashi and Nei 2000
). These results have previously been attributed to the complexity of the topology estimation problem (Yang 1997a
), but Bruno and Halpern (1999)
have suggested that they could be better understood in terms of bias toward the true tree when the assumptions of the method are violated; in other words, getting the right answer for the wrong reason.
There
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