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Molecular Biology and Evolution 18:271-275 (2001)
© 2001 Society for Molecular Biology and Evolution


LETTER

Simple (Wrong) Models for Complex Trees: A Case from Retroviridae

David Posada and Keith A. Crandall

Department of Zoology, Brigham Young University

Although the use of adequate models of evolution should improve the accuracy of phylogenetic inference (Leitner, Kumar, and Albert 1997Citation ; Sullivan and Swofford 1997Citation ; Cunningham, Zhu, and Hillis 1998Citation ), computer simulation studies have shown that under certain circumstances, wrong models can recover the true tree with higher probability than the tree model employed to generate the data (Saitou and Nei 1987Citation ; Schöniger and von Haeseler 1993Citation ; Tajima and Takezaki 1994Citation ; Tateno, Takezaki, and Nei 1994Citation ; Yang 1997aCitation ; Takahashi and Nei 2000Citation ). These results have previously been attributed to the complexity of the topology estimation problem (Yang 1997aCitation ), but Bruno and Halpern (1999)Citation have suggested that they could be better understood in terms of bias toward the true tree when the assumptions of the method are violated; in other words, getting the right answer for the wrong reason.

There . . . [Full Text of this Article]

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