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Molecular Biology and Evolution 18:2323-2326 (2001)
© 2001 Society for Molecular Biology and Evolution

Does the Recombination Rate Affect the Efficiency of Purifying Selection? The Yeast Genome Provides a Partial Answer

Csaba Pál, Balázs Papp and Laurence D. Hurst

Collegium Budapest, Institute for Advanced Study, Budapest, Hungary;
Department of Plant Taxonomy and Ecology, Eötvös Loránd University, Budapest, Hungary;
Department of Biology and Biochemistry, University of Bath, Bath, England

Much attention has been focused on the effect of recombination on preservation of favorable variants and on reducing the mutational load (Muller 1964Citation ; Kondrashov 1993Citation ; Barton 1995Citation ; Hurst and Peck 1996Citation ; West, Lively, and Read 1999Citation ). As most amino acid changes are slightly deleterious (Li 1997Citation ), their accumulation is expected to depend on the efficiency of purifying selection. Theoretical models have revealed that recombination might prevent the accumulation of such slightly deleterious mutations. This is potentially of importance because it suggests that purifying selection is less effective in genomic regions of low recombination (Hill and Robertson 1966Citation ; Carvalho and Clark 1999Citation ; Comeron, Kreitman, and Aguade 1999Citation ; Comeron and Kreitman 2000Citation ; Williams and Hurst 2000Citation ).

If purifying selection were more effective in regions of high recombination, accounting for within-genome variation, the rate of protein evolution should be lower in order . . . [Full Text of this Article]

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