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Molecular Biology and Evolution 18:2132-2135 (2001)
© 2001 Society for Molecular Biology and Evolution

The Correlation Between Linkage Disequilibrium and Distance: Implications for Recombination in Hominid Mitochondria

Julien Meunier and Adam Eyre-Walker

Ecole Normale Superieure de Lyon, Lyon, France;
Centre for the Study of Evolution and School of Biological Sciences, University of Sussex, Brighton, England

It is generally believed that the mitochondrial genome is inherited from a single parent in animals and higher plants and that the inheritance of mitochondrial DNA (mtDNA) is therefore clonal (Birky 1995Citation ). However, the clonality of human mtDNA has recently been questioned (Awadalla, Eyre-Walker, and Maynard Smith 1999Citation ; Eyre-Walker, Smith, and Maynard Smith 1999aCitation ; Hagelberg et al. 1999Citation ) and keenly debated (Eyre-Walker, Smith, and Maynard Smith 1999bCitation ; Macaulay, Richards, and Sykes 1999Citation ; Awadalla, Eyre-Walker, and Maynard Smith 2000Citation ; Eyre-Walker 2000Citation ; Jorde and Bamshad 2000Citation ; Kivisilid and Villems 2000Citation ; Kumar et al. 2000Citation ; Parsons and Irwin 2000Citation ).

The evidence of recombination in human mtDNA comes from two sources. First, many phylogenetic trees constructed using mtDNA contain a large amount of homoplasy (e.g., Vigilant et al. 1991Citation ; Ingman et al. 2000Citation ), which has generally been attributed . . . [Full Text of this Article]

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