Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (10)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Smith, N. G. C.
Right arrow Articles by Eyre-Walker, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Smith, N. G. C.
Right arrow Articles by Eyre-Walker, A.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Molecular Biology and Evolution 18:2124-2126 (2001)
© 2001 Society for Molecular Biology and Evolution

Nucleotide Substitution Rate Estimation in Enterobacteria: Approximate and Maximum-Likelihood Methods Lead to Similar Conclusions

Nick G. C. Smith and Adam Eyre-Walker

Centre for the Study of Evolution and School of Biological Sciences, University of Sussex, Brighton, England

Synonymous mutations are "silent" with regard to the amino acid sequence of a protein, but a wealth of evidence indicates that, at least in species with large effective population sizes, synonymous mutations are subject to translational selection (Akashi and Eyre-Walker 1998Citation ). One line of evidence for translational selection has been the perceived negative correlation between codon bias and synonymous substitution rates (KS), reported in both Drosophila (Shields et al. 1988Citation ) and enterobacteria (Sharp and Li 1987aCitation ). The reasoning behind this interpretation of the correlation between KS and codon bias is straightforward. Translational selection means that certain codons are favored over others, so selection causes an increased codon bias with a preponderance of favored codons, which means that most synonymous mutations are selectively disfavored and so selection also reduces KS.

The selective interpretation of the correlation between KS and codon bias in Drosophila has . . . [Full Text of this Article]

Acknowledgements

Footnotes

References


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 GeneticsHome page
C. E. Popescu, T. Borza, J. P. Bielawski, and R. W. Lee
Evolutionary Rates and Expression Level in Chlamydomonas
Genetics, March 1, 2006; 172(3): 1567 - 1576.
[Abstract] [Full Text] [PDF]

Home page
 Mol Biol EvolHome page
A. E. Hirsh, H. B. Fraser, and D. P. Wall
Adjusting for Selection on Synonymous Sites in Estimates of Evolutionary Distance
Mol. Biol. Evol., January 1, 2005; 22(1): 174 - 177.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
N. Bierne and A. Eyre-Walker
The Problem of Counting Sites in the Estimation of the Synonymous and Nonsynonymous Substitution Rates: Implications for the Correlation Between the Synonymous Substitution Rate and Codon Usage Bias
Genetics, November 1, 2003; 165(3): 1587 - 1597.
[Abstract] [Full Text] [PDF]

Home page
 Mol Biol EvolHome page
A. Mira and H. Ochman
Gene Location and Bacterial Sequence Divergence
Mol. Biol. Evol., August 1, 2002; 19(8): 1350 - 1358.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
J. Castresana
Genes on human chromosome 19 show extreme divergence from the mouse orthologs and a high GC content
Nucleic Acids Res., April 15, 2002; 30(8): 1751 - 1756.
[Abstract] [Full Text] [PDF]