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Molecular Biology and Evolution 18:2119-2123 (2001)
© 2001 Society for Molecular Biology and Evolution

A Relationship Between Lengths of Microsatellites and Nearby Substitution Rates in Mammalian Genomes

Mauro F. Santibáñez-Koref, Rathithevy Gangeswaran and John M. Hancock

Comparative Sequence Analysis Group, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, London, England

A number of studies have indicated an influence of sequences flanking tandem repeats on repeat stability (Monckton et al. 1994Citation ; Shimizu et al. 1996Citation ; Bowater et al. 1997Citation ; Jeffreys, Murray, and Neumann 1998Citation ; Kruglyak et al. 1998Citation ; Brock, Anderson, and Monckton 1999Citation ). In particular, Kruglyak et al. (1998)Citation have postulated a model to explain differences in average microsatellite length between species. According to this model, the average microsatellite length in a genome depends on two parameters: the tendency of microsatellites to undergo slippage-like mutation, and the rate of base substitution. We hypothesized that such a model might also apply within genomes, such that, for example, local variations in point substitution rate (Wolfe, Sharp, and Li 1989Citation ) could give rise to differences in average microsatellite length in different locations. To test this hypothesis, we investigated the relationship between microsatellite length and the substitution rates . . . [Full Text of this Article]

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