Molecular Biology and Evolution 18:89-93 (2001)
© 2001 Society for Molecular Biology and Evolution
LETTER |
Is Tetralogy True? Lack of Support for the "One-to-Four Rule"
Department of Environmental, Population, and Organismic Biology, University of Colorado
Many hypotheses proposed as explanations of gene family diversity in vertebrates invoke two successive polyploidizations prior to the origin of fishes (see references in Skrabanek and Wolfe 1998
; Martin 1999
). This hypothesis has gained widespread support in the literature. Spring (1997)
has advanced the term "tetralogy" as a definition of orthology in which the four paralogous gene copies in vertebrates are all homologous to single-copy genes in invertebrates. Nadeau and Sankoff (1997)
assumed successive genome duplications early in vertebrates in a study examining the relative rates of acquisition of new gene function and gene loss. Similarly, recent reviews on genome evolution emphasize the "one-to-four rule" (Meyer and Schartl 1999
), a rule that mirrors the intention of proposing tetralogy as an addition to the genomics vocabulary.
Recent papers have brought the issue of contemporary vertebrate genome organization into clearer focus and advocate adopting a hypothesis-testing framework for investigating
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