Molecular Biology and Evolution 17:1985-1987 (2000)
© 2000 Society for Molecular Biology and Evolution
Letter to the Editor |
Inferring Lifestyle from Gene Expression Patterns
Department of Biology, University of New Mexico and Santa Fe Institute
For many organisms, the primary locus of study is the laboratory, and not the organism's natural habitat. Through a century of laboratory studies, a huge body of knowledge has been accumulated for several "model organisms" of molecular and cell biology. This contrasts sharply with the often limited amount of information available on the ecology of such model organisms, a discrepancy that is particularly striking for microbes. Microbes arguably provide the bulk of our cell biological knowledge, but their natural habitats are poorly understood. Their physiology, their genomic gene content, and the structure of their genetic networks have been shaped over millions of years by natural selection in the wild. However, even for model microbes such as Escherichia coli and yeast, little is known about the ecological conditions under which they evolved. And because of the difference in laboratory and natural environments, laboratory experiments often have limited value in providing an
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