Molecular Biology and Evolution 17:1578-1579 (2000)
© 2000 Society for Molecular Biology and Evolution
Letter to the Editor |
Recombination and the Molecular Clock
,Department of Ecology and Genetics, University of Aarhus, Denmark
Much recent work focuses on the study of sequence evolution of fast-evolving RNA-based viruses such as HIV, influenza, and foot-and-mouth disease. From both an evolutionary and an epidemiological point of view, it is of interest to know whether sequences evolve according to a molecular clock or whether evolutionary rates vary among evolutionary lineages or over time. Present phylogenetic analyses based on the likelihood ratio test (Felsenstein 1981
; Huelsenbeck and Rannala 1997
) often reject a molecular clock (Elena, Gonzalezcandelas, and Moya 1992
; Holmes, Pybus, and Harvey 1999
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