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MBE Advance Access originally published online on May 6, 2009
Molecular Biology and Evolution 2009 26(8):1823-1827; doi:10.1093/molbev/msp096
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© The Author 2009. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

Research Articles

Detecting Ancient Admixture and Estimating Demographic Parameters in Multiple Human Populations

Jeffrey D. Wall*, Kirk E. Lohmueller{dagger},{ddagger} and Vincent Plagnol§

* Department of Epidemiology and Biostatistics, Institute for Human Genetics, University of California San Francisco
{dagger} Department of Molecular Biology and Genetics, Cornell University
{ddagger} Department of Biological Statistics and Computational Biology, Cornell University
§ Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom

E-mail: wallj{at}humgen.ucsf.edu.

Accepted for publication April 18, 2009.

We analyze patterns of genetic variation in extant human polymorphism data from the National Institute of Environmental Health Sciences single nucleotide polymorphism project to estimate human demographic parameters. We update our previous work by considering a larger data set (more genes and more populations) and by explicitly estimating the amount of putative admixture between modern humans and archaic human groups (e.g., Neandertals, Homo erectus, and Homo floresiensis). We find evidence for this ancient admixture in European, East Asian, and West African samples, suggesting that admixture between diverged hominin groups may be a general feature of recent human evolution.

Key Words: admixture • population structure • human evolution

Hideki Innan, Associate Editor


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