Skip Navigation



MBE Advance Access published online on April 18, 2008
Molecular Biology and Evolution, doi:10.1093/molbev/msn097
This Article
Right arrow Advance Access manuscript (PDF)
Right arrow Supplementary Data
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Mungpakdee, S.
Right arrow Articles by Chourrout, D.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Mungpakdee, S.
Right arrow Articles by Chourrout, D.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2008. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

Research Article

Differential Evolution of the Thirteen Atlantic Salmon Hox Clusters

Sutada Mungpakdee1, Hee-Chan Seo1,2,4, Anna Rita Angotzi1, Xianjun Dong3, Altuna Akalin3 and Daniel Chourrout1,4

1 Sars International Centre for Marine Molecular Biology, University of Bergen, Thormøhlensgt. 55, N-5008 Bergen, Norway
2 Department of Molecular Biology, University of Bergen, Thormøhlensgt. 55, P.O.Box 7803, N-5020 Bergen, Norway
3 Computational.Biology Unit, University of Bergen, Thormøhlensgt. 55, N-5008 Bergen, Norway

4 Corresponding authors: Daniel Chourrout (Tel. 5558 4313; Fax 5558 4305; Daniel.Chourrout{at}sars.uib.no) Hee-Chan Seo (Tel. 5558 4389; Fax 5558 9683; seo{at}mbi.uib.no) and

Received for publication December 19, 2007. Revision received February 28, 2008. Revision received March 25, 2008. Accepted for publication March 25, 2008.

Hox cluster organization represents a valuable marker to study the effects of recent genome duplication in salmonid fish (25-100 million years ago). Using PCR amplification of cDNAs, BAC library screening and genome walking, we reconstructed 13 Hox clusters in the Atlantic salmon containing 118 Hox genes including 8 pseudogenes. Hox paralogs resulting from the genome duplication preceding the radiation of ray-finned fish have been much better preserved in salmon than in other model teleosts. The last genome duplication in the salmon lineage has been followed by the loss of one of the four HoxA clusters. Four rounds of genome duplication after the vertebrate ancestor, salmon Hox clusters display the main organizational features of vertebrate Hox clusters, with Hox genes exclusively that are densely packed in the same orientation. Recently duplicated Hox clusters have engaged a process of divergence, with several cases of pseudogenization or asymmetrical evolution of Hox gene duplicates, and a marked erosion of identity in non-coding sequences. Strikingly, the level of divergence attained strongly depends on the Hox cluster pairs, rather than on the Hox genes within each cluster. It is particularly high between both HoxBb clusters and both HoxDa clusters, while both HoxBa clusters remained virtually identical. Positive selection on the Hox protein coding sequences could not be detected.

Key Words: Hox cluster • genome duplication • ray-finned fish • subfunctionalization • pseudogene


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.