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MBE Advance Access published online on October 6, 2004
Molecular Biology and Evolution, doi:10.1093/molbev/msi004
Molecular Biology and Evolution © Society for Molecular Biology and Evolution 2004; all rights reserved
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Accepted October 4, 2004

Letter

Comparative Analyses Reveal a Complex History of Molecular Evolution for Human MYH16

George H. Perry 1, Brian C. Verrelli 2, and Anne C. Stone 1*

1 Department of Anthropology, Arizona State University, Tempe, AZ
2 Center for Evolutionary Functional Genomics, The Biodesign Institute, Arizona State University, Tempe, AZ

* To whom correspondence should be addressed. E-mail: acstone{at}asu.edu.


  Abstract

We describe the pattern of molecular evolution at a sarcomeric myosin gene, MYH16, using more than 30,000 base pairs of exon and intron sequence data from the chimpanzee and human genome sequencing projects in order to evaluate the timing and consequences of a human lineage-specific frameshift deletion. We estimate the age of the deletion at approximately 5.3 million years ago. This estimate is consistent with the time of human and chimpanzee divergence, and is significantly older than the first appearance of the genus Homo in the fossil record. We also find conflicting estimates of nonsynonymous fixation rates (dN) across different regions of this gene, revealing a complex pattern inconsistent with a simple model of pseudogene evolution for human MYH16.

Keywords: MYH16; sarcomeric myosin; Pan troglodytes; Macaca mulatta.
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