MBE Advance Access published online on June 16, 2004
Molecular Biology and Evolution, doi:10.1093/molbev/msh192
Molecular Biology and Evolution © Society for Molecular Biology and Evolution 2004; all rights reserved
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1 Department of Ecology and Evolutionary Biology, University of Arizona, Biosciences West, Tucson, AZ 85721
* To whom correspondence should be addressed. E-mail: storz{at}sfsu.edu.
The last 50,000-150,000 yrs of human history have been characterized by rapid demographic expansions and the colonization of novel environments outside of sub-Saharan Africa. Mass migrations outside the ancestral species range likely entailed many new selection pressures, suggesting that genetic adaptation to local environmental conditions may have been more prevalent in colonizing populations outside of sub-Saharan Africa. Here we report a test of this hypothesis using genome-wide patterns of DNA polymorphism. We conducted a multilocus scan of microsatellite variability to identify regions of the human genome that may have been subject to continent-specific hitchhiking events. Using published polymorphism data for a total of 624 autosomal loci in multiple populations of humans, we used coalescent simulations to identify candidate loci for geographically restricted selective sweeps. We identified a total of 13 loci that appeared as outliers in replicated population comparisons involving different reference samples for Africa. A disproportionate number of these loci exhibited reduced levels of relative variability in non-African populations alone, suggesting that recent episodes of positive selection have been more prevalent outside of sub-Saharan Africa.
Original Articles
Genome Scans of DNA Variability in Humans Reveal Evidence for Selective Sweeps Outside of Africa
Abstract 
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  C.-H. Chen, T.-J. Chuang, B.-Y. Liao, and F.-C. Chen Scanning for the Signatures of Positive Selection for Human-Specific Insertions and Deletions Gen Biol Evol, March 1, 2010; 2009(0): 415 - 419. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. A. Payseur and P. Jing A Genomewide Comparison of Population Structure at STRPs and Nearby SNPs in Humans Mol. Biol. Evol., June 1, 2009; 26(6): 1369 - 1377. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Akey Constructing genomic maps of positive selection in humans: Where do we go from here? Genome Res., May 1, 2009; 19(5): 711 - 722. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Caballero, H. Quesada, and E. Rolan-Alvarez Impact of Amplified Fragment Length Polymorphism Size Homoplasy on the Estimation of Population Genetic Diversity and the Detection of Selective Loci Genetics, May 1, 2008; 179(1): 539 - 554. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. D. Jensen, K. R. Thornton, and C. F. Aquadro Inferring Selection in Partially Sequenced Regions Mol. Biol. Evol., February 1, 2008; 25(2): 438 - 446. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. J. Ryynanen, A. Tonteri, A. Vasemagi, and C. R. Primmer A Comparison of Biallelic Markers and Microsatellites for the Estimation of Population and Conservation Genetic Parameters in Atlantic Salmon (Salmo salar) J. Hered., November 5, 2007; (2007) esm093v1. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. C. Kane and L. H. Rieseberg Selective Sweeps Reveal Candidate Genes for Adaptation to Drought and Salt Tolerance in Common Sunflower, Helianthus annuus Genetics, April 1, 2007; 175(4): 1823 - 1834. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Yatabe, N. C. Kane, C. Scotti-Saintagne, and L. H. Rieseberg Rampant Gene Exchange Across a Strong Reproductive Barrier Between the Annual Sunflowers, Helianthus annuus and H. petiolaris Genetics, April 1, 2007; 175(4): 1883 - 1893. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. F. Baines and B. Harr Reduced X-Linked Diversity in Derived Populations of House Mice Genetics, April 1, 2007; 175(4): 1911 - 1921. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. L. Norton, R. A. Kittles, E. Parra, P. McKeigue, X. Mao, K. Cheng, V. A. Canfield, D. G. Bradley, B. McEvoy, and M. D. Shriver Genetic Evidence for the Convergent Evolution of Light Skin in Europeans and East Asians Mol. Biol. Evol., March 1, 2007; 24(3): 710 - 722. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. R. Thornton and J. D. Jensen Controlling the False-Positive Rate in Multilocus Genome Scans for Selection Genetics, February 1, 2007; 175(2): 737 - 750. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Wegmann, M. Currat, and L. Excoffier Molecular Diversity After a Range Expansion in Heterogeneous Environments Genetics, December 1, 2006; 174(4): 2009 - 2020. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Glinka, D. De Lorenzo, and W. Stephan Evidence of Gene Conversion Associated with a Selective Sweep in Drosophila melanogaster Mol. Biol. Evol., October 1, 2006; 23(10): 1869 - 1878. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Zhang, D. K. Bailey, T. Awad, G. Liu, G. Xing, M. Cao, V. Valmeekam, J. Retief, H. Matsuzaki, M. Taub, et al. A whole genome long-range haplotype (WGLRH) test for detecting imprints of positive selection in human populations Bioinformatics, September 1, 2006; 22(17): 2122 - 2128. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Kelley, J. Madeoy, J. C. Calhoun, W. Swanson, and J. M. Akey Genomic signatures of positive selection in humans and the limits of outlier approaches Genome Res., August 1, 2006; 16(8): 980 - 989. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Mekel-Bobrov, P. D. Evans, S. L. Gilbert, E. J. Vallender, R. R. Hudson, and B. T. Lahn Response to Comment on "Ongoing Adaptive Evolution of ASPM, a Brain Size Determinant in Homo sapiens" and "Microcephalin, a Gene Regulating Brain Size, Continues to Evolve Adaptively in Humans" Science, July 14, 2006; 313(5784): 172b - 172b. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Harr Genomic islands of differentiation between house mouse subspecies Genome Res., June 1, 2006; 16(6): 730 - 737. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. M. Teshima, G. Coop, and M. Przeworski How reliable are empirical genomic scans for selective sweeps? Genome Res., June 1, 2006; 16(6): 702 - 712. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. S. Pennings and J. Hermisson Soft Sweeps II--Molecular Population Genetics of Adaptation from Recurrent Mutation or Migration Mol. Biol. Evol., May 1, 2006; 23(5): 1076 - 1084. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. A. Reed and S. A. Tishkoff Positive Selection Can Create False Hotspots of Recombination Genetics, March 1, 2006; 172(3): 2011 - 2014. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Burke, S. J. Knapp, and L. H. Rieseberg Genetic Consequences of Selection During the Evolution of Cultivated Sunflower Genetics, December 1, 2005; 171(4): 1933 - 1940. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. J. C. Anderson, S. Nair, D. Sudimack, J. T. Williams, M. Mayxay, P. N. Newton, J.-P. Guthmann, F. M. Smithuis, T. T. Hien, I. V.F. van den Broek, et al. Geographical Distribution of Selected and Putatively Neutral SNPs in Southeast Asian Malaria Parasites Mol. Biol. Evol., December 1, 2005; 22(12): 2362 - 2374. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. D. Stump, M. C. Fitzpatrick, N. F. Lobo, S. Traore, N. Sagnon, C. Costantini, F. H. Collins, and N. J. Besansky Centromere-proximal differentiation and speciation in Anopheles gambiae PNAS, November 1, 2005; 102(44): 15930 - 15935. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. B. DuMont and C. F. Aquadro Multiple Signatures of Positive Selection Downstream of Notch on the X Chromosome in Drosophila melanogaster Genetics, October 1, 2005; 171(2): 639 - 653. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Li and W. Stephan Maximum-Likelihood Methods for Detecting Recent Positive Selection and Localizing the Selected Site in the Genome Genetics, September 1, 2005; 171(1): 377 - 384. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Ray, M. Currat, P. Berthier, and L. Excoffier Recovering the geographic origin of early modern humans by realistic and spatially explicit simulations Genome Res., August 1, 2005; 15(8): 1161 - 1167. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Cork and M. D. Purugganan High-Diversity Genes in the Arabidopsis Genome Genetics, August 1, 2005; 170(4): 1897 - 1911. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. R. Haddrill, K. R. Thornton, B. Charlesworth, and P. Andolfatto Multilocus patterns of nucleotide variability and the demographic and selection history of Drosophila melanogaster populations Genome Res., June 1, 2005; 15(6): 790 - 799. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Vasemagi, J. Nilsson, and C. R. Primmer Expressed Sequence Tag-Linked Microsatellites as a Source of Gene-Associated Polymorphisms for Detecting Signatures of Divergent Selection in Atlantic Salmon (Salmo salar L.) Mol. Biol. Evol., April 1, 2005; 22(4): 1067 - 1076. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. J. F. Verhoeven and K. L. Simonsen Genomic Haplotype Blocks May Not Accurately Reflect Spatial Variation in Historic Recombination Intensity Mol. Biol. Evol., March 1, 2005; 22(3): 735 - 740. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Karlsson and J. Mork Deviation from Hardy-Weinberg equilibrium, and temporal instability in allele frequencies at microsatellite loci in a local population of Atlantic cod ICES J. Mar. Sci., January 1, 2005; 62(8): 1588 - 1596. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. E. Stajich and M. W. Hahn Disentangling the Effects of Demography and Selection in Human History Mol. Biol. Evol., January 1, 2005; 22(1): 63 - 73. [Abstract] [Full Text] [PDF]
|
|