Molecular Biology and Evolution, Vol 9, 977-1017, Copyright © 1992 by Society for Molecular Biology and Evolution
H Green and P Djian
During the evolution of primates from nonprimates, the gene for involucrin
was greatly altered by changes in the short tandem repeats that are present
in some form in the gene of each of 17 species examined. The evolution of
involucrin was not the result of a single continuum of more or less random
changes, and it was not confined to the process of nucleotide substitution,
the most commonly studied evolutionary change in DNA. Instead, the
evolution of this gene took place through different mechanisms that
shortened the length of the repeats, increased their number, and changed
their codon sequence. As part of this trend, one entire segment of repeats
was replaced by another located elsewhere in the coding region. To bring
about these changes, specific mechanisms have been activated, deactivated,
and replaced by other mechanisms. The resulting serial revisions in the
involucrin gene must depend on gene-altering machinery whose synthesis or
activity can be controlled.
ORIGINAL ARTICLE
Consecutive actions of different gene-altering mechanisms in the evolution of involucrin
Department of Cellular and Molecular Physiology, Harvard Medical School, Boston, Massachusetts 02115.
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