Molecular Biology and Evolution, Vol 9, 753-769, Copyright © 1992 by Society for Molecular Biology and Evolution
GA Churchill, A von Haeseler and WC Navidi
The objective of this work is to describe sample-size calculations for the
inference of a nonzero central branch length in an unrooted four- species
phylogeny. Attention is restricted to independent binary characters, such
as might be obtained from an alignment of the purine- pyrimidine sequences
of a nucleic acid molecule. A statistical test based on a multinomial model
for character-state configurations is described. The importance of
including invariable sites in models for sequence change is demonstrated,
and their effect on sample size is quantified. The methods are applied to a
four-species alignment of small-subunit rRNA sequences derived from two
archaebacteria, a eubacteria and a eukaryote. We conclude that the
information in these sequences is not sufficient to resolve the branching
order of this tree. Estimates of the number of aligned nucleotide positions
required to provide a reasonably powerful test are given.
ORIGINAL ARTICLE
Sample size for a phylogenetic inference
Department of Plant Breeding and Biometry, Cornell University, Ithaca, New York 14853.
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