Molecular Biology and Evolution, Vol 9, 744-752, Copyright © 1992 by Society for Molecular Biology and Evolution
AG Clark and TS Whittam
Heuristic approaches were used to quantify the influence that sequencing
errors have on estimates of nucleotide diversity, substitution rate, and
the construction of genealogies. Error rates of less than 1 nucleotide/kb
probably have little affect on conclusions about the evolutionary history
of highly polymorphic organisms such as Drosophila and Escherichia coli,
but organisms with very low nucleotide diversity, such as humans, require
greater sequencing accuracy. A scan of GenBank for corrections of previous
errors reveals that sequencing errors are highly nonrandom.
ORIGINAL ARTICLE
Sequencing errors and molecular evolutionary analysis
Institute of Molecular Evolutionary Genetics, Pennsylvania State University, University Park 16802.
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