Molecular Biology and Evolution, Vol 9, 688-706, Copyright © 1992 by Society for Molecular Biology and Evolution
BG Hall and L Xu
The cryptic asc (previous called "SAC") operon of Escherichia coli K12 has
been completely sequenced. It encodes a repressor (ascG); a PTS enzyme
IIasc for the transport of arbutin, salicin, and cellobiose (ascF); and a
phospho-beta-glucosidase that hydrolyzes the sugars which are
phosphorylated during transport (ascB). ascG and ascFB are transcribed from
divergent promoters. The cryptic operon is activated by the insertion of
IS186 into the ascG (repressor) gene. The ascFB genes are paralogous to the
cryptic bglFB genes, and ascG is paralogous to galR. The duplications that
gave rise to these paralogous genes are estimated to have occurred
approximately 320 Mya, a time that predates the divergence of E. coli and
Salmonella typhimurium.
ORIGINAL ARTICLE
Nucleotide sequence, function, activation, and evolution of the cryptic asc operon of Escherichia coli K12
Biology Department, University of Rochester, New York 14627.
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